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Observe Closely (1)phenobarbital will lessen the level or impact of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead into a minimize in fentanyl plasma concentrations, not enough efficacy or, potentially, improvement